Thioredoxin-1 Gene Therapy Enhances Angiogenic Signaling and Reduces Ventricular Remodeling in Infarcted Myocardium of Diabetic Rats | Zendy

Samson Mathews Samuel | Zendy; Mahesh Thirunavukkarasu | Zendy; Suresh Varma Penumathsa | Zendy; Srikanth Koneru | Zendy; Lijun Zhan | Zendy; Gautam Maulik | Zendy; P. R. Sudhakaran | Zendy; Nilanjana Maulik | Zendy

Open Access

Thioredoxin-1 Gene Therapy Enhances Angiogenic Signaling and Reduces Ventricular Remodeling in Infarcted Myocardium of Diabetic Rats

Author(s) -

Samson Mathews Samuel,

Mahesh Thirunavukkarasu,

Suresh Varma Penumathsa,

Srikanth Koneru,

Lijun Zhan,

Gautam Maulik,

P. R. Sudhakaran,

Nilanjana Maulik

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.872481

Subject(s) - medicine , angiogenesis , thioredoxin , myocardial infarction , heme oxygenase , endocrinology , vascular endothelial growth factor , ventricular remodeling , cardiology , oxidative stress , heme , biology , biochemistry , vegf receptors , enzyme

The present study evaluated the reversal of diabetes-mediated impairment of angiogenesis in a myocardial infarction model of type 1 diabetic rats by intramyocardial administration of an adenoviral vector encoding thioredoxin-1 (Ad.Trx1). Various studies have linked diabetes-mediated impairment of angiogenesis to dysfunctional antioxidant systems in which thioredoxin-1 plays a central role.

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