Intracoronary Administration of Cardiac Progenitor Cells Alleviates Left Ventricular Dysfunction in Rats With a 30-Day-Old Infarction | Zendy

XianLiang Tang | Zendy; Gregg Rokosh | Zendy; Santosh K. Sanganalmath | Zendy; Fangping Yuan | Zendy; Hiroshi Sato | Zendy; Jianyao Mu | Zendy; Shujing Dai | Zendy; Chengxin Li | Zendy; Ning Chen | Zendy; Yong Peng | Zendy; Buddhadeb Dawn | Zendy; Greg Hunt | Zendy; Annarosa Leri | Zendy; Jan Kajstura | Zendy; Sumit Tiwari | Zendy; Gregg Shirk | Zendy; Piero Anversa | Zendy; Roberto Bolli | Zendy

Open Access

Intracoronary Administration of Cardiac Progenitor Cells Alleviates Left Ventricular Dysfunction in Rats With a 30-Day-Old Infarction

Author(s) -

XianLiang Tang,

Gregg Rokosh,

Santosh K. Sanganalmath,

Fangping Yuan,

Hiroshi Sato,

Jianyao Mu,

Shujing Dai,

Chengxin Li,

Ning Chen,

Yong Peng,

Buddhadeb Dawn,

Greg Hunt,

Annarosa Leri,

Jan Kajstura,

Sumit Tiwari,

Gregg Shirk,

Piero Anversa,

Roberto Bolli

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.871905

Subject(s) - medicine , myocardial infarction , endogeny , progenitor cell , cardiac function curve , cardiology , paracrine signalling , fibrosis , infarction , stem cell , heart failure , receptor , biology , genetics

Administration of cardiac progenitor cells (CPCs) 4 hours after reperfusion ameliorates left ventricular function in rats with acute myocardial infarction (MI). Clinically, however, this approach is not feasible, because expansion of autologous CPCs after acute MI requires several weeks. Therefore, we sought to determine whether CPCs are beneficial in the more clinically relevant setting of an old MI (scar).

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