Immunoglobulin M Is Required for Protection Against Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice | Zendy

Myles Lewis | Zendy; Talat H. Malik | Zendy; Michael R. Ehrenstein | Zendy; Joseph J. Boyle | Zendy; Marina Botto | Zendy; Dorian O. Haskard | Zendy

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Immunoglobulin M Is Required for Protection Against Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

Author(s) -

Myles Lewis,

Talat H. Malik,

Michael R. Ehrenstein,

Joseph J. Boyle,

Marina Botto,

Dorian O. Haskard

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.868158

Subject(s) - medicine , ldl receptor , antibody , low density lipoprotein , receptor , immunology , lipoprotein , endocrinology , cholesterol

Immunoglobulin M (IgM) natural antibodies bind oxidatively-modified low-density lipoprotein (LDL) and apoptotic cells and have been implicated as being important for protection against atherosclerosis. We have directly investigated the requirement for IgM by studying the effects of IgM deficiency in LDL receptor-deficient (Ldlr(-/-)) mice.

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