Hyperhomocysteinemia Promotes Inflammatory Monocyte Generation and Accelerates Atherosclerosis in Transgenic Cystathionine β-Synthase–Deficient Mice | Zendy

Daqing Zhang | Zendy; Xiaohua Jiang | Zendy; Pu Fang | Zendy; Yan Yan | Zendy; Jian Song | Zendy; Sapna Gupta | Zendy; Andrew I. Schafer | Zendy; William Durante | Zendy; Warren D. Kruger | Zendy; Xiaofeng Yang | Zendy; Hong Wang | Zendy

Open Access

Hyperhomocysteinemia Promotes Inflammatory Monocyte Generation and Accelerates Atherosclerosis in Transgenic Cystathionine β-Synthase–Deficient Mice

Author(s) -

Daqing Zhang,

Xiaohua Jiang,

Pu Fang,

Yan Yan,

Jian Song,

Sapna Gupta,

Andrew I. Schafer,

William Durante,

Warren D. Kruger,

Xiaofeng Yang,

Hong Wang

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.866889

Subject(s) - cystathionine beta synthase , hyperhomocysteinemia , medicine , homocysteine , monocyte , genetically modified mouse , inflammation , transgene , homocystinuria , immunology , enzyme , biochemistry , gene , methionine , biology , cysteine , amino acid

Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease. Monocytes display inflammatory and resident subsets and commit to specific functions in atherogenesis. In this study, we examined the hypothesis that HHcy modulates monocyte heterogeneity and leads to atherosclerosis.

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