Absence of Thrombospondin-2 Causes Age-Related Dilated Cardiomyopathy | Zendy

Melissa Swinnen | Zendy; Davy Vanhoutte | Zendy; Geert C. van Almen | Zendy; Nazha Hamdani | Zendy; Mark W.M. Schellings | Zendy; Jan D’hooge | Zendy; Jolanda van der Velden | Zendy; Matthew S. Weaver | Zendy; E. Helene Sage | Zendy; Paul Börnstein | Zendy; Fons K. Verheyen | Zendy; Thierry VandenDriessche | Zendy; Marinee Chuah | Zendy; Dirk Westermann | Zendy; Walter J. Paulus | Zendy; Frans Van de Werf | Zendy; Blanche Schroen | Zendy; Peter Carmeliet | Zendy; Yigal M. Pinto | Zendy; Stéphane Heymans | Zendy

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Absence of Thrombospondin-2 Causes Age-Related Dilated Cardiomyopathy

Author(s) -

Melissa Swinnen,

Davy Vanhoutte,

Geert C. van Almen,

Nazha Hamdani,

Mark W.M. Schellings,

Jan D’hooge,

Jolanda van der Velden,

Matthew S. Weaver,

E. Helene Sage,

Paul Börnstein,

Fons K. Verheyen,

Thierry VandenDriessche,

Marinee Chuah,

Dirk Westermann,

Walter J. Paulus,

Frans Van de Werf,

Blanche Schroen,

Peter Carmeliet,

Yigal M. Pinto,

Stéphane Heymans

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.863266

Subject(s) - dilated cardiomyopathy , medicine , cardiomyopathy , matricellular protein , endocrinology , cardiac function curve , heart failure , fibrosis , cardiac fibrosis , cardiology , extracellular matrix , biology , microbiology and biotechnology

The progressive shift from a young to an aged heart is characterized by alterations in the cardiac matrix. The present study investigated whether the matricellular protein thrombospondin-2 (TSP-2) may affect cardiac dimensions and function with physiological aging of the heart.

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