Soluble CD40 Ligand Impairs the Function of Peripheral Blood Angiogenic Outgrowth Cells and Increases Neointimal Formation After Arterial Injury | Zendy

Mihail Hristov | Zendy; Denis Gümbel | Zendy; Esther Lutgens | Zendy; Alma Zernecke | Zendy; Christian Weber | Zendy

Open Access

Soluble CD40 Ligand Impairs the Function of Peripheral Blood Angiogenic Outgrowth Cells and Increases Neointimal Formation After Arterial Injury

Author(s) -

Mihail Hristov,

Denis Gümbel,

Esther Lutgens,

Alma Zernecke,

Christian Weber

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.862771

Subject(s) - medicine , cd40 , peripheral blood , peripheral , ligand (biochemistry) , cardiology , in vitro , receptor , biochemistry , chemistry , cytotoxic t cell

Recent work has revealed an essential involvement of soluble CD40 ligand (sCD40L) in inflammation and atherosclerosis. We investigated whether sCD40L functionally affects peripheral blood-derived angiogenic early outgrowth cells (EOCs) and neointimal remodeling after arterial injury.

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