Upregulation of Matrix Metalloproteinase-2 in the Arterial Vasculature Contributes to Stiffening and Vasomotor Dysfunction in Patients With Chronic Kidney Disease | Zendy

Ada W.Y. Chung | Zendy; H.H. Clarice Yang | Zendy; Jong Moo Kim | Zendy; Mhairi K. Sigrist | Zendy; Elliott Chum | Zendy; William A. Gourlay | Zendy; Adeera Levin | Zendy

Open Access

Upregulation of Matrix Metalloproteinase-2 in the Arterial Vasculature Contributes to Stiffening and Vasomotor Dysfunction in Patients With Chronic Kidney Disease

Author(s) -

Ada W.Y. Chung,

H.H. Clarice Yang,

Jong Moo Kim,

Mhairi K. Sigrist,

Elliott Chum,

William A. Gourlay,

Adeera Levin

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.862565

Subject(s) - medicine , kidney disease , dialysis , kidney , renal function , endocrinology , hemodialysis , downregulation and upregulation , transplantation , contractility , arterial stiffness , urology , cardiology , blood pressure , biochemistry , gene , chemistry

Cardiovascular disease is the leading cause of mortality in chronic kidney disease patients on maintenance dialysis. Given the importance of matrix metalloproteinase-2 (MMP-2) in matrix integrity, vascular cell function, and structural stability, we hypothesized that MMP-2 was elevated in the macrovasculature in dialyzed chronic kidney disease patients compared with chronic kidney disease patients not on dialysis and kidney donors.

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