Priming With Angiopoietin-1 Augments the Vasculogenic Potential of the Peripheral Blood Stem Cells Mobilized With Granulocyte Colony-Stimulating Factor Through a Novel Tie2/Ets-1 Pathway | Zendy

Min-Seok Kim | Zendy; Choon-Soo Lee | Zendy; Jin Hur | Zendy; HyunJai Cho | Zendy; Soo-In Jun | Zendy; Tae Youn Kim | Zendy; Sae-Won Lee | Zendy; JungWon Suh | Zendy; Kyung Woo Park | Zendy; HaeYoung Lee | Zendy; HyunJae Kang | Zendy; Dong-Soo Lee | Zendy; Gou-Young Koh | Zendy; Hironori Nakagami | Zendy; Ryuichi Morishita | Zendy; Young-Bae Park | Zendy; Hyo-Soo Kim | Zendy

Open Access

Priming With Angiopoietin-1 Augments the Vasculogenic Potential of the Peripheral Blood Stem Cells Mobilized With Granulocyte Colony-Stimulating Factor Through a Novel Tie2/Ets-1 Pathway

Author(s) -

Min-Seok Kim,

Choon-Soo Lee,

Jin Hur,

HyunJai Cho,

Soo-In Jun,

Tae Youn Kim,

Sae-Won Lee,

JungWon Suh,

Kyung Woo Park,

HaeYoung Lee,

HyunJae Kang,

Dong-Soo Lee,

Gou-Young Koh,

Hironori Nakagami,

Ryuichi Morishita,

Young-Bae Park,

Hyo-Soo Kim

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.856815

Subject(s) - medicine , stem cell , angiopoietin , progenitor cell , priming (agriculture) , granulocyte colony stimulating factor , immunology , vascular endothelial growth factor , microbiology and biotechnology , biology , botany , germination , chemotherapy , vegf receptors

The low engraftment rate of stem/progenitor cells infused via the intracoronary route to the ischemic myocardium is one of the most important factors limiting the efficacy of cell therapy. We investigated the concept of priming peripheral blood stem cells enriched by granulocyte colony-stimulating factor mobilization and apheresis ((mob)PBSCs) with angiopoietin-1 (Ang1), to enhance the engraftment into the ischemic tissue and neovasculogenic potential.

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