1,25(OH) 2 Vitamin D Inhibits Foam Cell Formation and Suppresses Macrophage Cholesterol Uptake in Patients With Type 2 Diabetes Mellitus | Zendy

Jisu Oh | Zendy; Sherry Weng | Zendy; Shaili K. Felton | Zendy; Sweety Bhandare | Zendy; Amy E. Riek | Zendy; Boyd Butler | Zendy; Brandon M. Proctor | Zendy; Marvin Petty | Zendy; Zhouji Chen | Zendy; Kenneth B. Schechtman | Zendy; Leon BernalMizrachi | Zendy; Carlos BernalMizrachi | Zendy

Open Access

1,25(OH) ₂ Vitamin D Inhibits Foam Cell Formation and Suppresses Macrophage Cholesterol Uptake in Patients With Type 2 Diabetes Mellitus

Author(s) -

Jisu Oh,

Sherry Weng,

Shaili K. Felton,

Sweety Bhandare,

Amy E. Riek,

Boyd Butler,

Brandon M. Proctor,

Marvin Petty,

Zhouji Chen,

Kenneth B. Schechtman,

Leon BernalMizrachi,

Carlos BernalMizrachi

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.856070

Subject(s) - medicine , foam cell , macrophage , diabetes mellitus , vitamin d and neurology , cholesterol , type 2 diabetes mellitus , endocrinology , vitamin , cell , biochemistry , lipoprotein , in vitro , chemistry

Cardiovascular disease is the leading cause of death among those with diabetes mellitus. Vitamin D deficiency is associated with an increased risk of cardiovascular disease in this population. To determine the mechanism by which vitamin D deficiency mediates accelerated cardiovascular disease in patients with diabetes mellitus, we investigated the effects of active vitamin D on macrophage cholesterol deposition.

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