Transcription Factor Fos-Related Antigen-2 Induces Progressive Peripheral Vasculopathy in Mice Closely Resembling Human Systemic Sclerosis | Zendy

Britta Maurer | Zendy; Nicole Busch | Zendy; Astrid Jüngel | Zendy; Margarita Pileckytė | Zendy; Renate E. Gay | Zendy; Beat A. Michel | Zendy; Georg Schett | Zendy; Steffen Gay | Zendy; Jörg H. W. Distler | Zendy; Oliver Distler | Zendy

Open Access

Transcription Factor Fos-Related Antigen-2 Induces Progressive Peripheral Vasculopathy in Mice Closely Resembling Human Systemic Sclerosis

Author(s) -

Britta Maurer,

Nicole Busch,

Astrid Jüngel,

Margarita Pileckytė,

Renate E. Gay,

Beat A. Michel,

Georg Schett,

Steffen Gay,

Jörg H. W. Distler,

Oliver Distler

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.855114

Subject(s) - medicine , small interfering rna , endothelial stem cell , pathology , immunology , cancer research , biology , transfection , cell culture , in vitro , biochemistry , genetics

Microvascular damage is one of the first pathological changes in systemic sclerosis. In this study, we investigated the role of Fos-related antigen-2 (Fra-2), a transcription factor of the activator protein-1 family, in the peripheral vasculopathy of systemic sclerosis and examined the underlying mechanisms.

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