Accelerated Telomere Shortening in Leukocyte Subpopulations of Patients With Coronary Heart Disease | Zendy

Ioakim Spyridopoulos | Zendy; Jedrzej Hoffmann | Zendy; Alexandra Aicher | Zendy; Tim H. Brümmendorf | Zendy; Hans Wilhelm Doerr | Zendy; Andreas M. Zeiher | Zendy; Stefanie Dimmeler | Zendy

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Accelerated Telomere Shortening in Leukocyte Subpopulations of Patients With Coronary Heart Disease

Author(s) -

Ioakim Spyridopoulos,

Jedrzej Hoffmann,

Alexandra Aicher,

Tim H. Brümmendorf,

Hans Wilhelm Doerr,

Andreas M. Zeiher,

Stefanie Dimmeler

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.854299

Subject(s) - medicine , immunology , cd8 , cd34 , progenitor cell , telomere , stem cell , haematopoiesis , peripheral blood mononuclear cell , bone marrow , andrology , immune system , biology , genetics , dna , in vitro

Shortening of mean telomere length (TL) in white blood cells is correlated with the development of coronary heart disease (CHD) and with increased mortality due to infectious disease. The goal of the present study was to investigate whether telomere shortening in CHD is restricted to specific peripheral blood lymphocyte and/or myeloid cell subpopulations. Results were correlated to TL in CD34+ hematopoietic peripheral blood stem cells and progenitor cells obtained from the same individual patients.

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