Nitrite Therapy After Cardiac Arrest Reduces Reactive Oxygen Species Generation, Improves Cardiac and Neurological Function, and Enhances Survival via Reversible Inhibition of Mitochondrial Complex I | Zendy

Cameron Dezfulian | Zendy; Sruti Shiva | Zendy; Aleksey Alekseyenko | Zendy; Akshay Pendyal | Zendy; David G. Beiser | Zendy; Jeeva Munasinghe | Zendy; Stasia A. Anderson | Zendy; Christopher F. Chesley | Zendy; Terry L. Vanden Hoek | Zendy; Mark T. Gladwin | Zendy

Open Access

Nitrite Therapy After Cardiac Arrest Reduces Reactive Oxygen Species Generation, Improves Cardiac and Neurological Function, and Enhances Survival via Reversible Inhibition of Mitochondrial Complex I

Author(s) -

Cameron Dezfulian,

Sruti Shiva,

Aleksey Alekseyenko,

Akshay Pendyal,

David G. Beiser,

Jeeva Munasinghe,

Stasia A. Anderson,

Christopher F. Chesley,

Terry L. Vanden Hoek,

Mark T. Gladwin

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.853267

Subject(s) - medicine , asystole , cardiopulmonary resuscitation , anesthesia , cardiac function curve , resuscitation , hypothermia , ischemia , reperfusion injury , cardiology , heart failure

Three-fourths of cardiac arrest survivors die before hospital discharge or suffer significant neurological injury. Except for therapeutic hypothermia and revascularization, no novel therapies have been developed that improve survival or cardiac and neurological function after resuscitation. Nitrite (NO(2)(-)) increases cellular resilience to focal ischemia/reperfusion injury in multiple organs. We hypothesized that nitrite therapy may improve outcomes after the unique global ischemia/reperfusion insult of cardiopulmonary arrest.

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