Antenatal Sildenafil Treatment Attenuates Pulmonary Hypertension in Experimental Congenital Diaphragmatic Hernia | Zendy

Christina Luong | Zendy; Juliana Rey-Perra | Zendy; Arul Vadivel | Zendy; G. A. Gilmour | Zendy; Yves Sauvé | Zendy; Debby P.Y. Koonen | Zendy; Don K. Walker | Zendy; Kathryn G. Todd | Zendy; Pierre Gressèns | Zendy; Zamaneh Kassiri | Zendy; Khurram Nadeem | Zendy; Beverly C. Morgan | Zendy; Farah Eaton | Zendy; Jason R.B. Dyck | Zendy; Stephen L. Archer | Zendy; Bernard Thébaud | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Antenatal Sildenafil Treatment Attenuates Pulmonary Hypertension in Experimental Congenital Diaphragmatic Hernia

Author(s) -

Christina Luong,

Juliana Rey-Perra,

Arul Vadivel,

G. A. Gilmour,

Yves Sauvé,

Debby P.Y. Koonen,

Don K. Walker,

Kathryn G. Todd,

Pierre Gressèns,

Zamaneh Kassiri,

Khurram Nadeem,

Beverly C. Morgan,

Farah Eaton,

Jason R.B. Dyck,

Stephen L. Archer,

Bernard Thébaud

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.845909

Subject(s) - medicine , sildenafil , congenital diaphragmatic hernia , nitrofen , pulmonary hypertension , pulmonary artery , pulmonary hypoplasia , lung , right ventricular hypertrophy , nitric oxide , cardiology , fetus , cgmp specific phosphodiesterase type 5 , endocrinology , pregnancy , biology , genetics

Lung hypoplasia and persistent pulmonary hypertension of the newborn limit survival in congenital diaphragmatic hernia (CDH). Unlike other diseases resulting in persistent pulmonary hypertension of the newborn, infants with CDH are refractory to inhaled nitric oxide (NO). Nitric oxide mediates pulmonary vasodilatation at birth in part via cyclic GMP production. Phosphodiesterase type 5 (PDE5) limits the effects of NO by inactivation of cyclic GMP. Because of the limited success in postnatal management of CDH, we hypothesized that antenatal PDE5 inhibition would attenuate pulmonary artery remodeling in experimental nitrofen-induced CDH.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research