Platelet Dense-Granule Secretion Plays a Critical Role in Thrombosis and Subsequent Vascular Remodeling in Atherosclerotic Mice | Zendy

Sarah M. King | Zendy; Rachel McNamee | Zendy; Aiilyan K. Houng | Zendy; Rakesh Patel | Zendy; Michael W. Brands | Zendy; Guy L. Reed | Zendy

Open Access

Platelet Dense-Granule Secretion Plays a Critical Role in Thrombosis and Subsequent Vascular Remodeling in Atherosclerotic Mice

Author(s) -

Sarah M. King,

Rachel McNamee,

Aiilyan K. Houng,

Rakesh Patel,

Michael W. Brands,

Guy L. Reed

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.845461

Subject(s) - medicine , platelet , endocrinology , inflammation , platelet activation , p selectin , thrombosis , apolipoprotein e , disease

Platelet aggregation plays a critical role in myocardial infarction and stroke; however, the role of platelet secretion in atherosclerotic vascular disease is poorly understood. Therefore, we examined the hypothesis that platelet dense-granule secretion modulates thrombosis, inflammation, and atherosclerotic vascular remodeling after injury.

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