Peripheral Nociception Associated With Surgical Incision Elicits Remote Nonischemic Cardioprotection Via Neurogenic Activation of Protein Kinase C Signaling | Zendy

W. Keith Jones | Zendy; GuoChang Fan | Zendy; Siyun Liao | Zendy; Jun-Ming Zhang | Zendy; Yang Wang | Zendy; Neal L. Weintraub | Zendy; Evangelia G. Kranias | Zendy; Jo El J. Schultz | Zendy; John N. Lorenz | Zendy; Xiaoping Ren | Zendy

Open Access

Peripheral Nociception Associated With Surgical Incision Elicits Remote Nonischemic Cardioprotection Via Neurogenic Activation of Protein Kinase C Signaling

Author(s) -

W. Keith Jones,

GuoChang Fan,

Siyun Liao,

Jun-Ming Zhang,

Yang Wang,

Neal L. Weintraub,

Evangelia G. Kranias,

Jo El J. Schultz,

John N. Lorenz,

Xiaoping Ren

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.843938

Subject(s) - medicine , cardioprotection , nociception , peripheral , protein kinase a , anesthesia , kinase , pharmacology , cardiology , receptor , ischemia , microbiology and biotechnology , biology

Although remote ischemic stimuli have been shown to elicit cardioprotection against ischemia/reperfusion injury, there is little known about the effects of nonischemic stimuli. We previously described a remote cardioprotective effect of nonischemic surgical trauma (abdominal incision) called remote preconditioning of trauma (RPCT). In the present study, we elucidate mechanisms underlying this phenomenon.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research