Proteomic Analysis in Aortic Media of Patients With Marfan Syndrome Reveals Increased Activity of Calpain 2 in Aortic Aneurysms | Zendy

Christiane Pilop | Zendy; Fabienne Aregger | Zendy; Robert C. Gorman | Zendy; René Brunisholz | Zendy; Bertran Gerrits | Zendy; Thomas Schaffner | Zendy; Joseph H. Gorman | Zendy; Gábor Mátyás | Zendy; Thierry Carrel | Zendy; Brigitte M. Frey | Zendy

Open Access

Proteomic Analysis in Aortic Media of Patients With Marfan Syndrome Reveals Increased Activity of Calpain 2 in Aortic Aneurysms

Author(s) -

Christiane Pilop,

Fabienne Aregger,

Robert C. Gorman,

René Brunisholz,

Bertran Gerrits,

Thomas Schaffner,

Joseph H. Gorman,

Gábor Mátyás,

Thierry Carrel,

Brigitte M. Frey

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.843516

Subject(s) - bicuspid aortic valve , filamin , marfan syndrome , medicine , aorta , aortic valve , calpain , aortic aneurysm , cardiology , pathology , chemistry , biochemistry , cytoskeleton , cell , enzyme

Marfan syndrome (MFS) is a heritable disorder of connective tissue, affecting principally skeletal, ocular, and cardiovascular systems. The most life-threatening manifestations are aortic aneurysm and dissection. We investigated changes in the proteome of aortic media in patients with and without MFS to gain insight into molecular mechanisms leading to aortic dilatation.

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