Effect of Hypercholesterolemia on Myocardial Necrosis and Apoptosis in the Setting of Ischemia-Reperfusion | Zendy

Robert M. Osipov | Zendy; Cesario Bianchi | Zendy; Jun Feng | Zendy; Richard Clements | Zendy; Yuhong Liu | Zendy; Michael P. Robich | Zendy; Hilary Glazer | Zendy; Neel R. Sodha | Zendy; Frank W. Sellke | Zendy

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Effect of Hypercholesterolemia on Myocardial Necrosis and Apoptosis in the Setting of Ischemia-Reperfusion

Author(s) -

Robert M. Osipov,

Cesario Bianchi,

Jun Feng,

Richard Clements,

Yuhong Liu,

Michael P. Robich,

Hilary Glazer,

Neel R. Sodha,

Frank W. Sellke

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.842724

Subject(s) - medicine , tunel assay , ischemia , oxidative stress , enos , apoptosis , necrosis , endocrinology , western blot , myocardial infarction , p38 mitogen activated protein kinases , cardiology , mapk/erk pathway , immunohistochemistry , signal transduction , nitric oxide , biochemistry , nitric oxide synthase , biology , gene

Hypercholesterolemia is prevalent in patients who experience myocardial ischemia-reperfusion injury (IR). We investigate the impact of dietary-induced hypercholesterolemia on the myocardium in the setting of acute IR.

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