Markers of Autophagy Are Downregulated in Failing Human Heart After Mechanical Unloading | Zendy

Christos Kassiotis | Zendy; Kalpana Ballal | Zendy; Kari Wellnitz | Zendy; Deborah Vela | Zendy; Mei Gong | Zendy; Rebecca Salazar | Zendy; O.H. Frazier | Zendy; Heinrich Taegtmeyer | Zendy

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Markers of Autophagy Are Downregulated in Failing Human Heart After Mechanical Unloading

Author(s) -

Christos Kassiotis,

Kalpana Ballal,

Kari Wellnitz,

Deborah Vela,

Mei Gong,

Rebecca Salazar,

O.H. Frazier,

Heinrich Taegtmeyer

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.842252

Subject(s) - autophagy , atg5 , medicine , tunel assay , heart failure , cardiomyopathy , apoptosis , blot , endocrinology , microbiology and biotechnology , andrology , immunohistochemistry , biology , gene , biochemistry

Autophagy is a molecular process that breaks down damaged cellular organelles and yields amino acids for de novo protein synthesis or energy provision. Mechanical unloading with a left ventricular assist device (LVAD) decreases the energy demand of the failing human heart. We tested the hypothesis that LVAD support reverses activation of autophagy.

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