Open Accessp27 kip1 –838C>A Single Nucleotide Polymorphism Is Associated With Restenosis Risk After Coronary Stenting and Modulates p27 kip1 Promoter Activity
Author(s) -
Claudia M. van Tiel,
Peter I. Bonta,
Saskia Z.H. Rittersma,
Marcel A.M. Beijk,
Edward J. Bradley,
Anita Klous,
Karel T. Koch,
Frank Baas,
J. Wouter Jukema,
Douwe Pons,
M. Lourdes Sampietro,
Hans Pannekoek,
Robbert J. de Winter,
Carlie J.M. de Vries
Publication year - 2009
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.108.842179
Subject(s) - single nucleotide polymorphism , restenosis , medicine , hazard ratio , genotype , confidence interval , stent , cardiology , genetics , biology , gene
The cyclin-dependent kinase inhibitor p27(kip1) is a key regulator of smooth muscle cell and leukocyte proliferation in vascular disease, including in-stent restenosis. We therefore hypothesized that common genetic variations or single nucleotide polymorphisms in p27(kip1) may serve as a useful tool in risk stratification for in-stent restenosis.