Tobacco Smoke Exposure in Either the Donor or Recipient Before Transplantation Accelerates Cardiac Allograft Rejection, Vascular Inflammation, and Graft Loss | Zendy

Ashwani Khanna | Zendy; Jianping Xu | Zendy; Patricia A. Uber | Zendy; Allen Burke | Zendy; Claudia R. Baquet | Zendy; Mandeep R. Mehra | Zendy

Open Access

Tobacco Smoke Exposure in Either the Donor or Recipient Before Transplantation Accelerates Cardiac Allograft Rejection, Vascular Inflammation, and Graft Loss

Author(s) -

Ashwani Khanna,

Jianping Xu,

Patricia A. Uber,

Allen Burke,

Claudia R. Baquet,

Mandeep R. Mehra

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.840223

Subject(s) - medicine , transplantation , inflammation , immunology , heart transplantation , tumor necrosis factor alpha , tobacco smoke , pathology , environmental health

Tobacco exposure in cardiac transplant recipients, before and after transplantation, may increase the risk of cardiac allograft vasculopathy and allograft loss, but no direct evidence for this phenomenon is forthcoming. In this experimental study, we investigated early consequences of tobacco smoke exposure in cardiac transplant donors and recipients with an emphasis on alloinflammatory mediators of graft outcome.

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