Matrix Metalloproteinase-7 and ADAM-12 (a Disintegrin and Metalloproteinase-12) Define a Signaling Axis in Agonist-Induced Hypertension and Cardiac Hypertrophy | Zendy

Xiang Wang | Zendy; Fung L. Chow | Zendy; Tatsujiro Oka | Zendy; Hao Li | Zendy; Ana Lopez-Campistrous | Zendy; Sandra Kelly | Zendy; Stephan Cooper | Zendy; Jeffrey Odenbach | Zendy; Barry A. Finegan | Zendy; Richard Schulz | Zendy; Zamaneh Kassiri | Zendy; Gary D. Lopaschuk | Zendy; Carlos Fernández-Patrón | Zendy

Open Access

Matrix Metalloproteinase-7 and ADAM-12 (a Disintegrin and Metalloproteinase-12) Define a Signaling Axis in Agonist-Induced Hypertension and Cardiac Hypertrophy

Author(s) -

Xiang Wang,

Fung L. Chow,

Tatsujiro Oka,

Hao Li,

Ana Lopez-Campistrous,

Sandra Kelly,

Stephan Cooper,

Jeffrey Odenbach,

Barry A. Finegan,

Richard Schulz,

Zamaneh Kassiri,

Gary D. Lopaschuk,

Carlos Fernández-Patrón

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.835488

Subject(s) - disintegrin , medicine , metalloproteinase , matrix metalloproteinase , agonist , matrix metalloproteinase 9 , matrix metalloproteinase 3 , endocrinology , receptor

Excessive stimulation of Gq protein-coupled receptors by cognate vasoconstrictor agonists induces a variety of cardiovascular processes, including hypertension and hypertrophy. Here, we report that matrix metalloproteinase-7 (MMP-7) and a disintegrin and metalloproteinase-12 (ADAM-12) form a novel signaling axis in these processes.

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