Regulation of the Human Cardiac Mitochondrial Ca 2+ Uptake by 2 Different Voltage-Gated Ca 2+ Channels | Zendy

Guido Michels | Zendy; Ismail Khan | Zendy; Jeannette Endres-Becker | Zendy; Dennis Rottlaender | Zendy; Stefan Herzig | Zendy; Arjang Ruhparwar | Zendy; Thorsten Wahlers | Zendy; Uta C. Hoppe | Zendy

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Regulation of the Human Cardiac Mitochondrial Ca ²⁺ Uptake by 2 Different Voltage-Gated Ca ²⁺ Channels

Author(s) -

Guido Michels,

Ismail Khan,

Jeannette Endres-Becker,

Dennis Rottlaender,

Stefan Herzig,

Arjang Ruhparwar,

Thorsten Wahlers,

Uta C. Hoppe

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.835389

Subject(s) - medicine , mitochondrion , biophysics , microbiology and biotechnology , biology

Impairment of intracellular Ca(2+) homeostasis and mitochondrial function has been implicated in the development of cardiomyopathy. Mitochondrial Ca(2+) uptake is thought to be mediated by the Ca(2+) uniporter (MCU) and a thus far speculative non-MCU pathway. However, the identity and properties of these pathways are a matter of intense debate, and possible functional alterations in diseased states have remained elusive.

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