Complement-Dependent Neutrophil Recruitment Is Critical for the Development of Elastase-Induced Abdominal Aortic Aneurysm | Zendy

Monica B. Pagano | Zendy; Huifang Zhou | Zendy; Terri L. Ennis | Zendy; Xiaobo Wu | Zendy; John D. Lambris | Zendy; John Atkinson | Zendy; Robert W. Thompson | Zendy; Dennis E. Hourcade | Zendy; Christine T. N. Pham | Zendy

Open Access

Complement-Dependent Neutrophil Recruitment Is Critical for the Development of Elastase-Induced Abdominal Aortic Aneurysm

Author(s) -

Monica B. Pagano,

Huifang Zhou,

Terri L. Ennis,

Xiaobo Wu,

John D. Lambris,

John Atkinson,

Robert W. Thompson,

Dennis E. Hourcade,

Christine T. N. Pham

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.832972

Subject(s) - medicine , abdominal aortic aneurysm , elastase , neutrophil elastase , aortic aneurysm , complement (music) , aneurysm , cardiology , inflammation , aorta , radiology , biochemistry , enzyme , chemistry , phenotype , complementation , gene

We previously established that neutrophils play a critical role in the development of experimental abdominal aortic aneurysm (AAA). The signal that initiates the influx of neutrophils to the aortic wall, however, remains unknown. In this study, we tested the hypothesis that complement participates in the development of AAA by providing the necessary chemotactic signal that recruits neutrophils to the aortic wall.

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