Reactive Oxygen Species–Induced Stimulation of 5′AMP-Activated Protein Kinase Mediates Sevoflurane-Induced Cardioprotection | Zendy

Regis R. Lamberts | Zendy; Geert Onderwater | Zendy; Nazha Hamdani | Zendy; M. Jumoke A. Vreden | Zendy; Jeroen Steenhuisen | Zendy; Etto C. Eringa | Zendy; Stephan A. Loer | Zendy; Ger J.M. Stienen | Zendy; R. Arthur Bouwman | Zendy

Open Access

Reactive Oxygen Species–Induced Stimulation of 5′AMP-Activated Protein Kinase Mediates Sevoflurane-Induced Cardioprotection

Author(s) -

Regis R. Lamberts,

Geert Onderwater,

Nazha Hamdani,

M. Jumoke A. Vreden,

Jeroen Steenhuisen,

Etto C. Eringa,

Stephan A. Loer,

Ger J.M. Stienen,

R. Arthur Bouwman

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.828426

Subject(s) - cardioprotection , ampk , sevoflurane , medicine , ischemic preconditioning , ischemia , protein kinase a , phosphorylation , pharmacology , endocrinology , anesthesia , biochemistry , chemistry

5'AMP-activated protein kinase (AMPK), a well-known regulator of cellular energy status, is also implicated in ischemic preconditioning leading to cardioprotection. We hypothesized that AMPK is involved in anesthetic-induced cardioprotection and that this activation is mediated by reactive oxygen species (ROS).

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