Detoxification and Endothelialization of Glutaraldehyde-Fixed Bovine Pericardium With Titanium Coating | Zendy

Norbert W. Guldner | Zendy; Inka Jasmund | Zendy; H. Zimmermann | Zendy; Markus Heinlein | Zendy; B Girndt | Zendy; Veronika Meier | Zendy; F Flüß | Zendy; Daniel Rohde | Zendy; Andreas Gebert | Zendy; HansHinrich Sievers | Zendy

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Detoxification and Endothelialization of Glutaraldehyde-Fixed Bovine Pericardium With Titanium Coating

Author(s) -

Norbert W. Guldner,

Inka Jasmund,

H. Zimmermann,

Markus Heinlein,

B Girndt,

Veronika Meier,

F Flüß,

Daniel Rohde,

Andreas Gebert,

HansHinrich Sievers

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.823948

Subject(s) - glutaraldehyde , citric acid , biocompatibility , titanium , medicine , aldehyde dehydrogenase , nuclear chemistry , biochemistry , materials science , chemistry , metallurgy , pathology , enzyme

Endothelial cell seeding of glutardialdehyde-fixed biological heart valves is hypothesized to improve biocompatibility and durability; however, the toxicity of glutardialdehyde prevents its use as a biological coating. Therefore, different detoxification strategies are applied, including surface coating with titanium, before in vitro endothelialization of glutaraldehyde-fixed bovine pericardium as the base material for prosthetic heart valves.

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