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Monocyte activation and migration into the arterial wall are key events in atherogenesis associated with hypercholesterolemia. CD11c/CD18, a beta2 integrin expressed on human monocytes and a subset of mouse monocytes, has been shown to play a distinct role in human monocyte adhesion on endothelial cells, but the regulation of CD11c in hypercholesterolemia and its role in atherogenesis are unknown.

Functional Role of CD11c + Monocytes in Atherogenesis Associated With Hypercholesterolemia

Functional Role of CD11c ⁺ Monocytes in Atherogenesis Associated With Hypercholesterolemia