Functional Role of CD11c + Monocytes in Atherogenesis Associated With Hypercholesterolemia | Zendy

Huaizhu Wu | Zendy; R. Michael Gower | Zendy; Hong Wang | Zendy; Xiao-Yuan Dai Perrard | Zendy; Ruidong Ma | Zendy; Daniel C. Bullard | Zendy; Alan R. Burns | Zendy; Antoni Paul | Zendy; C. Wayne Smith | Zendy; Scott I. Simon | Zendy; Christie M. Ballantyne | Zendy

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Functional Role of CD11c ⁺ Monocytes in Atherogenesis Associated With Hypercholesterolemia

Author(s) -

Huaizhu Wu,

R. Michael Gower,

Hong Wang,

Xiao-Yuan Dai Perrard,

Ruidong Ma,

Daniel C. Bullard,

Alan R. Burns,

Antoni Paul,

C. Wayne Smith,

Scott I. Simon,

Christie M. Ballantyne

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.823740

Subject(s) - medicine , atherosclerotic cardiovascular disease , monocyte , immunology , disease

Monocyte activation and migration into the arterial wall are key events in atherogenesis associated with hypercholesterolemia. CD11c/CD18, a beta2 integrin expressed on human monocytes and a subset of mouse monocytes, has been shown to play a distinct role in human monocyte adhesion on endothelial cells, but the regulation of CD11c in hypercholesterolemia and its role in atherogenesis are unknown.

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