Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging | Zendy

DaoFu Dai | Zendy; Luis F. Santana | Zendy; Marc Vermulst | Zendy; Daniela M. Tomazela | Zendy; Mary J. Emond | Zendy; Michael J. MacCoss | Zendy; Katherine A. Gollahon | Zendy; George M. Martin | Zendy; Lawrence A. Loeb | Zendy; Warren Ladiges | Zendy; Peter S. Rabinovitch | Zendy

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Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

Author(s) -

DaoFu Dai,

Luis F. Santana,

Marc Vermulst,

Daniela M. Tomazela,

Mary J. Emond,

Michael J. MacCoss,

Katherine A. Gollahon,

George M. Martin,

Lawrence A. Loeb,

Warren Ladiges,

Peter S. Rabinovitch

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.822403

Subject(s) - reactive oxygen species , medicine , mitochondrion , mitochondrial biogenesis , catalase , cardiac function curve , mitochondrial ros , oxidative stress , senescence , endocrinology , mitochondrial dna , cardiology , biology , heart failure , microbiology and biotechnology , biochemistry , gene

Age is a major risk for cardiovascular diseases. Although mitochondrial reactive oxygen species have been proposed as one of the causes of aging, their role in cardiac aging remains unclear. We have previously shown that overexpression of catalase targeted to mitochondria (mCAT) prolongs murine median lifespan by 17% to 21%.

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