Diabetes Mellitus Activates Signal Transduction Pathways Resulting in Vascular Endothelial Growth Factor Resistance of Human Monocytes | Zendy

Vadim Tchaikovski | Zendy; Servé Olieslagers | Zendy; Frank -D. Böhmer | Zendy; Johannes Waltenberger | Zendy

Open Access

Diabetes Mellitus Activates Signal Transduction Pathways Resulting in Vascular Endothelial Growth Factor Resistance of Human Monocytes

Author(s) -

Vadim Tchaikovski,

Servé Olieslagers,

Frank -D. Böhmer,

Johannes Waltenberger

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.817528

Subject(s) - protein tyrosine phosphatase , vascular endothelial growth factor , protein kinase b , medicine , endocrinology , tyrosine phosphorylation , signal transduction , monocyte , microbiology and biotechnology , receptor , biology , vegf receptors

Monocytes are cellular components of wound repair, arteriogenesis, and atherogenesis. Vascular endothelial growth factor (VEGF)-A and placental growth factor recruit monocytes to sites of arteriogenesis via stimulation of VEGF receptor-1 (VEGFR-1). The chemotactic response of monocytes to VEGF-A is attenuated in individuals with diabetes mellitus (DM). This VEGF resistance correlates with impaired collateral growth. The aim of this study is to elucidate the molecular basis of VEGF resistance and impaired monocyte response in DM.

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