Vascular Smooth Muscle Cell–Selective Peroxisome Proliferator–Activated Receptor-γ Deletion Leads to Hypotension | Zendy

Lin Chang | Zendy; Luis Villacorta | Zendy; Jifeng Zhang | Zendy; Minerva T. Garcia-Barrio | Zendy; Kun Yang | Zendy; Michael R. Hamblin | Zendy; Steven E. Whitesall | Zendy; Louis G. D’Alecy | Zendy; Y. Eugene Chen | Zendy

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Vascular Smooth Muscle Cell–Selective Peroxisome Proliferator–Activated Receptor-γ Deletion Leads to Hypotension

Author(s) -

Lin Chang,

Luis Villacorta,

Jifeng Zhang,

Minerva T. Garcia-Barrio,

Kun Yang,

Michael R. Hamblin,

Steven E. Whitesall,

Louis G. D’Alecy,

Y. Eugene Chen

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.815803

Subject(s) - vascular smooth muscle , peroxisome proliferator activated receptor , endocrinology , medicine , receptor , smooth muscle

Peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists are commonly used to treat diabetes, although their PPARgamma-dependent effects transcend their role as insulin sensitizers. Thiazolidinediones lower blood pressure (BP) in diabetic patients, whereas results from conventional/tissue-specific PPARgamma experimental models suggest an important pleiotropic role for PPARgamma in BP control. Little evidence is available on the molecular mechanisms underlying the role of vascular smooth muscle cell-specific PPARgamma in basal vascular tone.

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