Role of NADPH Oxidase in Endothelial Ischemia/Reperfusion Injury in Humans | Zendy

Stavros Loukogeorgakis | Zendy; J. Merlijn van den Berg | Zendy; Reecha Sofat | Zendy; Dorothea Nitsch | Zendy; Marietta Charakida | Zendy; Bu’Hussein Haiyee | Zendy; Eric de Groot | Zendy; Raymond J. MacAllister | Zendy; Taco W. Kuijpers | Zendy; John Deanfield | Zendy

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Role of NADPH Oxidase in Endothelial Ischemia/Reperfusion Injury in Humans

Author(s) -

Stavros Loukogeorgakis,

J. Merlijn van den Berg,

Reecha Sofat,

Dorothea Nitsch,

Marietta Charakida,

Bu’Hussein Haiyee,

Eric de Groot,

Raymond J. MacAllister,

Taco W. Kuijpers,

John Deanfield

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.814731

Subject(s) - medicine , ischemia , reperfusion injury , nadph oxidase , cardiology , oxidative stress

Reactive oxygen species have been implicated in the pathogenesis of ischemia/reperfusion (IR) injury. Recent studies suggest that NADPH oxidase may be a source of ROS during IR. Using an in vivo model of endothelial IR injury in the arm, we compared the response to IR in healthy volunteers with that in patients with chronic granulomatous disease. These patients have a molecular lesion in a subunit of NADPH oxidase that renders the enzyme inactive.

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