Reciprocal Regulation of Myocardial microRNAs and Messenger RNA in Human Cardiomyopathy and Reversal of the microRNA Signature by Biomechanical Support | Zendy

Scot J. Matkovich | Zendy; Derek J. Van Booven | Zendy; Keith A. Youker | Zendy; Guillermo TorreAmione | Zendy; Abhinav Diwan | Zendy; William H. Eschenbacher | Zendy; Lisa E. Dorn | Zendy; Mark A. Watson | Zendy; Kenneth B. Margulies | Zendy; Gerald W. Dorn | Zendy

Open Access

Reciprocal Regulation of Myocardial microRNAs and Messenger RNA in Human Cardiomyopathy and Reversal of the microRNA Signature by Biomechanical Support

Author(s) -

Scot J. Matkovich,

Derek J. Van Booven,

Keith A. Youker,

Guillermo TorreAmione,

Abhinav Diwan,

William H. Eschenbacher,

Lisa E. Dorn,

Mark A. Watson,

Kenneth B. Margulies,

Gerald W. Dorn

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.813576

Subject(s) - microrna , heart failure , medicine , gene expression profiling , cardiomyopathy , messenger rna , cardiology , gene expression , microarray , downregulation and upregulation , ischemic cardiomyopathy , bioinformatics , gene , biology , ejection fraction , genetics

Much has been learned about transcriptional control of cardiac gene expression in clinical and experimental congestive heart failure (CHF), but less is known about dynamic regulation of microRNAs (miRs) in CHF and during CHF treatment. We performed comprehensive microarray profiling of miRs and messenger RNAs (mRNAs) in myocardial specimens from human CHF with (n=10) or without (n=17) biomechanical support from left ventricular assist devices in comparison to nonfailing hearts (n=11).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research