MTHFR 677 C>T Polymorphism Reveals Functional Importance for 5-Methyltetrahydrofolate, Not Homocysteine, in Regulation of Vascular Redox State and Endothelial Function in Human Atherosclerosis | Zendy

Charalambos Antoniades | Zendy; Cheerag Shirodaria | Zendy; Paul Leeson | Zendy; O Baarholm | Zendy; Tim Van-Assche | Zendy; Colin Cunnington | Zendy; Ravi Pillai | Zendy; C Ratnatunga | Zendy; Dimitris Tousoulis | Zendy; Christodoulos Stefanadis | Zendy; Helga Refsum | Zendy; Keith M. Chan | Zendy

Open Access

MTHFR 677 C>T Polymorphism Reveals Functional Importance for 5-Methyltetrahydrofolate, Not Homocysteine, in Regulation of Vascular Redox State and Endothelial Function in Human Atherosclerosis

Author(s) -

Charalambos Antoniades,

Cheerag Shirodaria,

Paul Leeson,

O Baarholm,

Tim Van-Assche,

Colin Cunnington,

Ravi Pillai,

C Ratnatunga,

Dimitris Tousoulis,

Christodoulos Stefanadis,

Helga Refsum,

Keith M. Chan

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.808675

Subject(s) - homocysteine , methylenetetrahydrofolate reductase , nitric oxide , medicine , nitric oxide synthase , endocrinology , vascular disease , endothelium , endothelial dysfunction , hyperhomocysteinemia , superoxide , biology , pharmacology , biochemistry , enzyme , genotype , gene

The role of circulating homocysteine as an atherosclerosis risk factor has recently been questioned. However, 5-methyl-tetrahydrofolate (5-MTHF), the circulating metabolite of folic acid participating in homocysteine metabolism, has direct effects on vascular function. We sought to distinguish the effects of plasma versus vascular tissue 5-MTHF and homocysteine on vascular redox and endothelial nitric oxide bioavailability in human vessels.

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