Conventional Dendritic Cells at the Crossroads Between Immunity and Cholesterol Homeostasis in Atherosclerosis | Zendy

Emmanuel L. Gautier | Zendy; Thierry Huby | Zendy; Flora Saint-Charles | Zendy; B. Ouzilleau | Zendy; John Pirault | Zendy; Virginie Deswaerte | Zendy; Florent Ginhoux | Zendy; Elizabeth R. Miller | Zendy; Joseph L. Witztum | Zendy; M. John Chapman | Zendy; Philippe Lesnik | Zendy

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Conventional Dendritic Cells at the Crossroads Between Immunity and Cholesterol Homeostasis in Atherosclerosis

Author(s) -

Emmanuel L. Gautier,

Thierry Huby,

Flora Saint-Charles,

B. Ouzilleau,

John Pirault,

Virginie Deswaerte,

Florent Ginhoux,

Elizabeth R. Miller,

Joseph L. Witztum,

M. John Chapman,

Philippe Lesnik

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.807537

Subject(s) - medicine , homeostasis , immunity , cholesterol , immune system , immunology

Immunoinflammatory mechanisms are implicated in the atherogenic process. The polarization of the immune response and the nature of the immune cells involved, however, are major determinants of the net effect, which may be either proatherogenic or antiatherogenic. Dendritic cells (DCs) are central to the regulation of immunity, the polarization of the immune response, and the induction of tolerance to antigens. The potential role of DCs in atherosclerosis, however, remains to be defined.

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