Soluble CXCL16 Predicts Long-Term Mortality in Acute Coronary Syndromes | Zendy

Anna Jansson | Zendy; Pål Aukrust | Zendy; Thor Ueland | Zendy; Camilla Smith | Zendy; Torbjørn Omland | Zendy; Marianne Hartford | Zendy; Kenneth Caidahl | Zendy

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Soluble CXCL16 Predicts Long-Term Mortality in Acute Coronary Syndromes

Author(s) -

Anna Jansson,

Pål Aukrust,

Thor Ueland,

Camilla Smith,

Torbjørn Omland,

Marianne Hartford,

Kenneth Caidahl

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.806877

Subject(s) - cxcl16 , medicine , hazard ratio , myocardial infarction , cardiology , heart failure , proportional hazards model , unstable angina , chemokine , inflammation , confidence interval , chemokine receptor

CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor for oxidized low-density lipoprotein that is expressed in atherosclerotic lesions. Proteolytic cleavage of membrane-bound CXCL16 releases soluble CXCL16, which may promote migration of effector T cells and augment a proatherogenic inflammatory response. We hypothesized that soluble CXCL16 concentrations are associated with long-term outcome in patients with acute coronary syndromes.

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