Open AccessMacrophage Apoptosis Exerts Divergent Effects on Atherogenesis as a Function of Lesion Stage
Author(s) -
Emmanuel L. Gautier,
Thierry Huby,
Joseph L. Witztum,
B. Ouzilleau,
Elizabeth R. Miller,
Flora Saint-Charles,
Pièrre Aucouturier,
M. John Chapman,
Philippe Lesnik
Publication year - 2009
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.108.806158
Subject(s) - apoptosis , medicine , macrophage , lesion , fatty streak , inflammation , chemokine , pathology , immunology , cancer research , in vitro , biology , biochemistry
Because apoptotic cell clearance appears to be defective in advanced compared with early atherosclerotic plaques, macrophage apoptosis may differentially affect plaque progression as a function of lesion stage.
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