Pioglitazone Improves Cardiac Function and Alters Myocardial Substrate Metabolism Without Affecting Cardiac Triglyceride Accumulation and High-Energy Phosphate Metabolism in Patients With Well-Controlled Type 2 Diabetes Mellitus | Zendy

R.W. van der Meer | Zendy; Luuk J. Rijzewijk | Zendy; Hugo W. A. M. de Jong | Zendy; Hildo J. Lamb | Zendy; Mark Lubberink | Zendy; Johannes A. Romijn | Zendy; Jeroen J. Bax | Zendy; Albert de Roos | Zendy; Otto Kamp | Zendy; Walter J. Paulus | Zendy; Robert J. Heine | Zendy; Adriaan A. Lammertsma | Zendy; Johannes W. A. Smit | Zendy; Michaëla Diamant | Zendy

Open Access

Pioglitazone Improves Cardiac Function and Alters Myocardial Substrate Metabolism Without Affecting Cardiac Triglyceride Accumulation and High-Energy Phosphate Metabolism in Patients With Well-Controlled Type 2 Diabetes Mellitus

Author(s) -

R.W. van der Meer,

Luuk J. Rijzewijk,

Hugo W. A. M. de Jong,

Hildo J. Lamb,

Mark Lubberink,

Johannes A. Romijn,

Jeroen J. Bax,

Albert de Roos,

Otto Kamp,

Walter J. Paulus,

Robert J. Heine,

Adriaan A. Lammertsma,

Johannes W. A. Smit,

Michaëla Diamant

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.803916

Subject(s) - pioglitazone , medicine , endocrinology , metformin , diabetic cardiomyopathy , cardiology , diabetes mellitus , cardiac function curve , type 2 diabetes mellitus , heart failure , insulin resistance , triglyceride , type 2 diabetes , insulin , cardiomyopathy , cholesterol

Cardiac disease is the leading cause of mortality in type 2 diabetes mellitus (T2DM). Pioglitazone has been associated with improved cardiac outcome but also with an elevated risk of heart failure. We determined the effects of pioglitazone on myocardial function in relation to cardiac high-energy phosphate, glucose, and fatty acid metabolism and triglyceride content in T2DM patients.

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