Stress Doppler Echocardiography in Relatives of Patients With Idiopathic and Familial Pulmonary Arterial Hypertension | Zendy

Ekkehard Grünig | Zendy; Sylvia Weissmann | Zendy; Nicola Ehlken | Zendy; Anna Fijałkowska | Zendy; Christine Fischer | Zendy; Thierry Fourme | Zendy; Nazzareno Galiè | Zendy; Hossein A. Ghofrani | Zendy; Rachel E. Harrison | Zendy; Sandrine Huez | Zendy; Marc Humbert | Zendy; Bart Janssen | Zendy; Jarosław Kober | Zendy; Rolf Koehler | Zendy; Rajiv D. Machado | Zendy; Derliz Mereles | Zendy; Robert Naeije | Zendy; Horst Olschewski | Zendy; Steeve Provencher | Zendy; Frank Reichenberger | Zendy; Kathleen Retailleau | Zendy; Guido Rocchi | Zendy; Gérald Simonneau | Zendy; Adam Torbicki | Zendy; Richard C. Trembath | Zendy; Werner Seeger | Zendy

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Stress Doppler Echocardiography in Relatives of Patients With Idiopathic and Familial Pulmonary Arterial Hypertension

Author(s) -

Ekkehard Grünig,

Sylvia Weissmann,

Nicola Ehlken,

Anna Fijałkowska,

Christine Fischer,

Thierry Fourme,

Nazzareno Galiè,

Hossein A. Ghofrani,

Rachel E. Harrison,

Sandrine Huez,

Marc Humbert,

Bart Janssen,

Jarosław Kober,

Rolf Koehler,

Rajiv D. Machado,

Derliz Mereles,

Robert Naeije,

Horst Olschewski,

Steeve Provencher,

Frank Reichenberger,

Kathleen Retailleau,

Guido Rocchi,

Gérald Simonneau,

Adam Torbicki,

Richard C. Trembath,

Werner Seeger

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.800938

Subject(s) - medicine , cardiology , pulmonary hypertension , doppler echocardiography , stress echocardiography , pulmonary arterial pressure , blood pressure , diastole , coronary artery disease

This large, prospective, multicentric study was performed to analyze the distribution of tricuspid regurgitation velocity (TRV) values during exercise and hypoxia in relatives of patients with idiopathic and familial pulmonary arterial hypertension (PAH) and in healthy control subjects. We tested the hypothesis that relatives of idiopathic/familial PAH patients display an enhanced frequency of hypertensive TRV response to stress and that this response is associated with mutations in the bone morphogenetic protein receptor II (BMPR2) gene.

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