Disruption of Striated Preferentially Expressed Gene Locus Leads to Dilated Cardiomyopathy in Mice
Author(s) -
Xiaoli Liu,
Tripurasundari Ramjiganesh,
YenHsu Chen,
Su Wol Chung,
Sean R. R. Hall,
Scott L. Schissel,
Robert F. Padera,
Ronglih Liao,
Kate G. Ackerman,
Jan Kajstura,
Annarosa Leri,
Piero Anversa,
ShawFang Yet,
Matthew D. Layne,
Mark A. Perrella
Publication year - 2009
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.108.799536
Subject(s) - gene isoform , locus (genetics) , exon , mutant , gene , myocyte , dilated cardiomyopathy , alternative splicing , biology , myofibril , cardiomyopathy , microbiology and biotechnology , gene expression , phenotype , medicine , endocrinology , genetics , heart failure
The striated preferentially expressed gene (Speg) generates 4 different isoforms through alternative promoter use and tissue-specific splicing. Depending on the cell type, Speg isoforms may serve as markers of striated or smooth muscle differentiation.
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