Open AccessRepolarization Reserve
Author(s) -
Dan M. Roden
Publication year - 2008
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.108.798918
Subject(s) - medicine , cardiology , benign early repolarization , ventricular repolarization , repolarization , myocardial infarction , electrophysiology , st segment
A drug dose (and con-centration) that produces minimal QT prolongation in onepatient may, in an apparently indistinguishable subject, pro-duce marked QT prolongation and torsade de pointes. Thisvariability in response to an exogenous stressor is paralleledby variability in the extent to which a given mutation in thecongenital long-QT syndrome prolongs QT interval andcauses arrhythmias.
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