Metformin Prevents Progression of Heart Failure in Dogs | Zendy

H. Sasaki | Zendy; Hiroshi Asanuma | Zendy; Masashi Fujita | Zendy; Hiroyuki Takahama | Zendy; Masakatsu Wakeno | Zendy; Shin Ito | Zendy; Akiko Ogai | Zendy; Masanori Asakura | Zendy; Jiyoong Kim | Zendy; Tetsuo Minamino | Zendy; Seiji Takashima | Zendy; Shoji Sanada | Zendy; Masaru Sugimachi | Zendy; Kazuo Komamura | Zendy; Naoki Mochizuki | Zendy; Masafumi Kitakaze | Zendy

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Metformin Prevents Progression of Heart Failure in Dogs

Author(s) -

H. Sasaki,

Hiroshi Asanuma,

Masashi Fujita,

Hiroyuki Takahama,

Masakatsu Wakeno,

Shin Ito,

Akiko Ogai,

Masanori Asakura,

Jiyoong Kim,

Tetsuo Minamino,

Seiji Takashima,

Shoji Sanada,

Masaru Sugimachi,

Kazuo Komamura,

Naoki Mochizuki,

Masafumi Kitakaze

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.798561

Subject(s) - metformin , ampk , medicine , heart failure , endocrinology , apoptosis , amp activated protein kinase , myocardial infarction , nitric oxide , protein kinase a , diabetes mellitus , phosphorylation , biology , microbiology and biotechnology , biochemistry

Some studies have shown that metformin activates AMP-activated protein kinase (AMPK) and has a potent cardioprotective effect against ischemia/reperfusion injury. Because AMPK also is activated in animal models of heart failure, we investigated whether metformin decreases cardiomyocyte apoptosis and attenuates the progression of heart failure in dogs.

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