Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages | Zendy

Laurent YvanCharvet | Zendy; Carrie L. Welch | Zendy; Tamara A. Pagler | Zendy; Mollie Ranalletta | Zendy; Mohamed Lamkanfi | Zendy; Seongah Han | Zendy; Minako Ishibashi | Zendy; Rong Li | Zendy; Nan Wang | Zendy; Alan R. Tall | Zendy

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Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages

Author(s) -

Laurent YvanCharvet,

Carrie L. Welch,

Tamara A. Pagler,

Mollie Ranalletta,

Mohamed Lamkanfi,

Seongah Han,

Minako Ishibashi,

Rong Li,

Nan Wang,

Alan R. Tall

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.793869

Subject(s) - medicine , gene expression , gene , inflammation , transporter , atp binding cassette transporter , immunology , genetics , biology

Two macrophage ABC transporters, ABCA1 and ABCG1, have a major role in promoting cholesterol efflux from macrophages. Peritoneal macrophages deficient in ABCA1, ABCG1, or both show enhanced expression of inflammatory and chemokine genes. This study was undertaken to elucidate the mechanisms and consequences of enhanced inflammatory gene expression in ABC transporter-deficient macrophages.

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