Increased Vascular Senescence and Impaired Endothelial Progenitor Cell Function Mediated by Mutation of Circadian Gene Per2 | Zendy

ChaoYung Wang | Zendy; MingShien Wen | Zendy; Hongwei Wang | Zendy; ChingLin Hsieh | Zendy; Yuxin Li | Zendy; PingYen Liu | Zendy; FunChung Lin | Zendy; James K. Liao | Zendy

Open Access

Increased Vascular Senescence and Impaired Endothelial Progenitor Cell Function Mediated by Mutation of Circadian Gene Per2

Author(s) -

ChaoYung Wang,

MingShien Wen,

Hongwei Wang,

ChingLin Hsieh,

Yuxin Li,

PingYen Liu,

FunChung Lin,

James K. Liao

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.790469

Subject(s) - per2 , medicine , endocrinology , transplantation , progenitor cell , senescence , circadian rhythm , angiogenesis , stem cell , biology , clock , circadian clock , microbiology and biotechnology

Alteration of the circadian rhythm and increased vascular senescence are linked to cardiovascular disease. Per2, a circadian gene, is known to regulate endothelium-dependent vasomotion. However, the mechanism by which Per2 affects endothelial function is unknown. We hypothesize that endothelial dysfunction in Per2 mutant (Per2(m/m)) mice is mediated in part by increased vascular senescence and impaired endothelial progenitor cell (EPC) function.

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