Funny Current Downregulation and Sinus Node Dysfunction Associated With Atrial Tachyarrhythmia | Zendy

YungHsin Yeh | Zendy; Brett Burstein | Zendy; Xiao Yan Qi | Zendy; Masao Sakabe | Zendy; Denis Chartier | Zendy; Philippe Comtois | Zendy; Zhiguo Wang | Zendy; Chi-Tai Kuo | Zendy; Stanley Nattel | Zendy

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Funny Current Downregulation and Sinus Node Dysfunction Associated With Atrial Tachyarrhythmia

Author(s) -

YungHsin Yeh,

Brett Burstein,

Xiao Yan Qi,

Masao Sakabe,

Denis Chartier,

Philippe Comtois,

Zhiguo Wang,

Chi-Tai Kuo,

Stanley Nattel

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.789677

Subject(s) - medicine , cardiology , electrophysiology , connexin , protein subunit , endocrinology , sinoatrial node , gap junction , heart rate , biology , gene , microbiology and biotechnology , biochemistry , intracellular , blood pressure

Sinoatrial node (SAN) dysfunction is frequently associated with atrial tachyarrhythmias (ATs). Abnormalities in SAN pacemaker function after termination of ATs can cause syncope and require pacemaker implantation, but underlying mechanisms remain poorly understood. This study examined the hypothesis that ATs impair SAN function by altering ion channel expression.

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