Inhibition of Protein Kinase Cβ Prevents Foam Cell Formation by Reducing Scavenger Receptor A Expression in Human Macrophages | Zendy

Elena Osto | Zendy; Alexei Kouroedov | Zendy; Pavani Mocharla | Zendy; Alexander Akhmedov | Zendy; Christian Besler | Zendy; Lucia Rohrer | Zendy; Arnold von Eckardstein | Zendy; Sabino Iliceto | Zendy; Massimo Volpe | Zendy; Thomas F. Lüscher | Zendy; Francesco Cosentino | Zendy

Open Access

Inhibition of Protein Kinase Cβ Prevents Foam Cell Formation by Reducing Scavenger Receptor A Expression in Human Macrophages

Author(s) -

Elena Osto,

Alexei Kouroedov,

Pavani Mocharla,

Alexander Akhmedov,

Christian Besler,

Lucia Rohrer,

Arnold von Eckardstein,

Sabino Iliceto,

Massimo Volpe,

Thomas F. Lüscher,

Francesco Cosentino

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.789537

Subject(s) - monocyte , scavenger receptor , protein kinase c , phorbol , foam cell , microbiology and biotechnology , lipoprotein , signal transduction , medicine , chemistry , biology , biochemistry , cholesterol

Low-density lipoprotein (LDL) uptake by monocyte-derived macrophages is a crucial step in foam cell formation and early atherosclerotic lesion. Increasing evidence supports the theory that activation of protein kinase Cbeta (PKCbeta) is involved in many mechanisms promoting atherosclerosis. Thus, we investigated whether inhibition of PKCbeta prevents foam cell formation.

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