Electrophysiological Consequences of Acute Regional Ischemia/Reperfusion in Neonatal Rat Ventricular Myocyte Monolayers | Zendy

Carlos De Diego | Zendy; Rakesh K. Pai | Zendy; Fuhua Chen | Zendy; LaiHua Xie | Zendy; Jan de Leeuw | Zendy; James N. Weiss | Zendy; Miguel Valderrábano | Zendy

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Electrophysiological Consequences of Acute Regional Ischemia/Reperfusion in Neonatal Rat Ventricular Myocyte Monolayers

Author(s) -

Carlos De Diego,

Rakesh K. Pai,

Fuhua Chen,

LaiHua Xie,

Jan de Leeuw,

James N. Weiss,

Miguel Valderrábano

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.789149

Subject(s) - medicine , electrophysiology , cardiology , ischemia , myocyte

Electrophysiological changes promoting arrhythmias during acute regional ischemia/reperfusion are challenging to study in intact cardiac tissue because of complex 3-dimensional myocardial and vascular geometry. We characterized electrophysiological alterations and arrhythmias during regional ischemia/reperfusion in a simpler 2-dimensional geometry of cultured neonatal rat ventricular myocyte monolayers.

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