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Endogenous adenosine can protect the overloaded heart against the development of hypertrophy and heart failure, but the contribution of A(1) receptors (A(1)R) and A(3) receptors (A(3)R) is not known.

Adenosine A 3 Receptor Deficiency Exerts Unanticipated Protective Effects on the Pressure-Overloaded Left Ventricle

Adenosine A ₃ Receptor Deficiency Exerts Unanticipated Protective Effects on the Pressure-Overloaded Left Ventricle