Novel Small Interfering RNA–Containing Solution Protecting Donor Organs in Heart Transplantation | Zendy

Xiufen Zheng | Zendy; Dameng Lian | Zendy; Arthur Wong | Zendy; Michael Bygrave | Zendy; Thomas E. Ichim | Zendy; Mahdieh Khoshniat | Zendy; Xusheng Zhang | Zendy; Hongtao Sun | Zendy; Tobias De Zordo | Zendy; James C. Lacefield | Zendy; Bertha García | Zendy; Anthony M. Jevnikar | Zendy; WeiPing Min | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Novel Small Interfering RNA–Containing Solution Protecting Donor Organs in Heart Transplantation

Author(s) -

Xiufen Zheng,

Dameng Lian,

Arthur Wong,

Michael Bygrave,

Thomas E. Ichim,

Mahdieh Khoshniat,

Xusheng Zhang,

Hongtao Sun,

Tobias De Zordo,

James C. Lacefield,

Bertha García,

Anthony M. Jevnikar,

WeiPing Min

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.787390

Subject(s) - transplantation , small interfering rna , medicine , reperfusion injury , viaspan , ischemia , tumor necrosis factor alpha , gene expression , cold storage , rna interference , rna , immunology , surgery , gene , biology , biochemistry , horticulture

Ischemia/reperfusion injury is a major factor in graft quality and subsequent function in the transplantation setting. We hypothesize that the process of RNA interference may be used to "engineer" a graft to suppress expression of genes associated with inflammation, apoptosis, and complement, which are believed to cause ischemia/reperfusion injury. Such manipulation of pathological gene expression may be performed by treatment of the graft ex vivo with small interfering RNA (siRNA) as part of the preservation procedure.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research