Critical Role of Transcription Factor Cyclic AMP Response Element Modulator in β 1 -Adrenoceptor–Mediated Cardiac Dysfunction | Zendy

Geertje Lewin | Zendy; Marek Máťuš | Zendy; Abhijit Basu | Zendy; Karin Frebel | Zendy; Sebastian Pius Rohsbach | Zendy; Andrej Safronenko | Zendy; Matthias D. Seidl | Zendy; Frank Stümpel | Zendy; Igor Buchwalow | Zendy; Simone König | Zendy; Stefan Engelhardt | Zendy; Martin J. Lohse | Zendy; Wilhelm Schmitz | Zendy; Frank U. Müller | Zendy

Open Access

Critical Role of Transcription Factor Cyclic AMP Response Element Modulator in β ₁ -Adrenoceptor–Mediated Cardiac Dysfunction

Author(s) -

Geertje Lewin,

Marek Máťuš,

Abhijit Basu,

Karin Frebel,

Sebastian Pius Rohsbach,

Andrej Safronenko,

Matthias D. Seidl,

Frank Stümpel,

Igor Buchwalow,

Simone König,

Stefan Engelhardt,

Martin J. Lohse,

Wilhelm Schmitz,

Frank U. Müller

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.786533

Subject(s) - creb , transcription factor , endocrinology , medicine , gene expression , genetically modified mouse , heart failure , transgene , microbiology and biotechnology , biology , gene , genetics

Chronic stimulation of the beta(1)-adrenoceptor (beta(1)AR) plays a crucial role in the pathogenesis of heart failure; however, underlying mechanisms remain to be elucidated. The regulation by transcription factors cAMP response element-binding protein (CREB) and cyclic AMP response element modulator (CREM) represents a fundamental mechanism of cyclic AMP-dependent gene control possibly implicated in beta(1)AR-mediated cardiac deterioration.

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