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Chronic stimulation of the beta(1)-adrenoceptor (beta(1)AR) plays a crucial role in the pathogenesis of heart failure; however, underlying mechanisms remain to be elucidated. The regulation by transcription factors cAMP response element-binding protein (CREB) and cyclic AMP response element modulator (CREM) represents a fundamental mechanism of cyclic AMP-dependent gene control possibly implicated in beta(1)AR-mediated cardiac deterioration.

Critical Role of Transcription Factor Cyclic AMP Response Element Modulator in β 1 -Adrenoceptor–Mediated Cardiac Dysfunction

Critical Role of Transcription Factor Cyclic AMP Response Element Modulator in β ₁ -Adrenoceptor–Mediated Cardiac Dysfunction