Long-Term Cardiac-Targeted RNA Interference for the Treatment of Heart Failure Restores Cardiac Function and Reduces Pathological Hypertrophy | Zendy

Lennart Suckau | Zendy; Henry Fechner | Zendy; Elie R. Chemaly | Zendy; Stefanie Krohn | Zendy; Lahouaria Hadri | Zendy; Jens Kockskämper | Zendy; Dirk Westermann | Zendy; Egbert Bisping | Zendy; Hung Q. Ly | Zendy; Xiaomin Wang | Zendy; Yoshiaki Kawase | Zendy; Jiqiu Chen | Zendy; Lifan Liang | Zendy; Isaac Sipo | Zendy; Roland Vetter | Zendy; Stefan Weger | Zendy; Jens Kurreck | Zendy; Volker A. Erdmann | Zendy; Carsten Tschöpe | Zendy; Burkert Pieske | Zendy; Djamel Lebeche | Zendy; HeinzPeter Schultheiss | Zendy; Roger J. Hajjar | Zendy; Wolfgang Poller | Zendy

Open Access

Long-Term Cardiac-Targeted RNA Interference for the Treatment of Heart Failure Restores Cardiac Function and Reduces Pathological Hypertrophy

Author(s) -

Lennart Suckau,

Henry Fechner,

Elie R. Chemaly,

Stefanie Krohn,

Lahouaria Hadri,

Jens Kockskämper,

Dirk Westermann,

Egbert Bisping,

Hung Q. Ly,

Xiaomin Wang,

Yoshiaki Kawase,

Jiqiu Chen,

Lifan Liang,

Isaac Sipo,

Roland Vetter,

Stefan Weger,

Jens Kurreck,

Volker A. Erdmann,

Carsten Tschöpe,

Burkert Pieske,

Djamel Lebeche,

HeinzPeter Schultheiss,

Roger J. Hajjar,

Wolfgang Poller

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.783852

Subject(s) - phospholamban , heart failure , rna interference , medicine , cardiac function curve , small hairpin rna , genetic enhancement , pressure overload , cardiology , pharmacology , biology , cardiac hypertrophy , rna , biochemistry , gene

RNA interference (RNAi) has the potential to be a novel therapeutic strategy in diverse areas of medicine. Here, we report on targeted RNAi for the treatment of heart failure, an important disorder in humans that results from multiple causes. Successful treatment of heart failure is demonstrated in a rat model of transaortic banding by RNAi targeting of phospholamban, a key regulator of cardiac Ca(2+) homeostasis. Whereas gene therapy rests on recombinant protein expression as its basic principle, RNAi therapy uses regulatory RNAs to achieve its effect.

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