Dialysis Accelerates Medial Vascular Calcification in Part by Triggering Smooth Muscle Cell Apoptosis | Zendy

Rukshana Shroff | Zendy; Rosamund McNair | Zendy; Nichola Figg | Zendy; Jeremy N. Skepper | Zendy; Leon J. Schurgers | Zendy; A Gupta | Zendy; Melanie P. Hiorns | Zendy; Ann E. Donald | Zendy; John Deanfield | Zendy; Lesley Rees | Zendy; Catherine M. Shanahan | Zendy

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Dialysis Accelerates Medial Vascular Calcification in Part by Triggering Smooth Muscle Cell Apoptosis

Author(s) -

Rukshana Shroff,

Rosamund McNair,

Nichola Figg,

Jeremy N. Skepper,

Leon J. Schurgers,

A Gupta,

Melanie P. Hiorns,

Ann E. Donald,

John Deanfield,

Lesley Rees,

Catherine M. Shanahan

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.783738

Subject(s) - calcification , medicine , vascular smooth muscle , dialysis , apoptosis , kidney disease , pathogenesis , pathology , programmed cell death , endocrinology , biology , biochemistry , smooth muscle

Vascular calcification is associated with increased morbidity and mortality in stage V chronic kidney disease, yet its early pathogenesis and initiating mechanisms in vivo remain poorly understood. To address this, we quantified the calcium (Ca) load in arteries from children (10 predialysis, 24 dialysis) and correlated it with clinical, biochemical, and vascular measures.

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